ea0099rc2.6 | Rapid Communications 2: Calcium and Bone | Part I | ECE2024
Gobbo Alberto
, Chamekh Fatima
, Cattaneo Camilla Alice
, Verrienti Martina
, Pizzicotti Stefano
, Longo Filomena
, Chiara Zatelli Maria
, Ambrosio Maria Rosaria
Introduction: Patients with transfusion-dependent β-thalassemia (TDT) frequently exhibit elevated urinary calcium excretion, contributing to kidney stone formation and osteoporosis. The underlying mechanism of hypercalciuria in β-thalassemia remains elusive, with FGF23 playing a potential role. FGF23, a bone-derived hormone, primarily acts on the kidneys by inhibiting phosphate reabsorption in the proximal tubules while enhancing calcium uptake in the distal tubules....